Objective To study the effect of Lianzhu Granule on gut barrier function in rats suffered from endotoxaemia enteritis.Methods Fifty Sprague-Dawley rats were randomly divided into 5 groups: Normal control group

model group

Lianzhu Granule 3.6g/kg

1.8g/kg and 0.9g/kg groups

10 in each. Rat models of intestinal catarrh were established by injecting lipo polysaccharide （LPS） via the peritoneal injection after gastric infusion twice a day for 3 days. The times of diarrhea

Na+

K+

Cl-

hematocrit

nitric oxide （NO）

diamine oxidase （DAO）

D-Lactate density in the blood

the IgA plasma cell （PC） and SIgA content of small intestine were measured 4 hours after LPS injection.Results The times of diarrhea in the model group were significantly higher than those of the normal control group （P<0.01）

while those of the Lianzhu Granule groups were lowered （P<0.05 or P<0.01）. The levels of glucose

Na+

K+

Cl-and hematocrit in the model group were lower than those of the normal control group （P<0.05 or P<0.01）

while those of Lianzhu Granule groups were significantly improved. The levels of NO

DAO and D-lactate of the model group were higher than those of the normal control group （P<0.05）

while those of Lianzhu Granule groups were significantly lower （P<0.01）.Conclusion Lianzhu Granule has a protective function for intestinal mucosa impairment caused by LPS through decreasing the intensity of inflammatory reaction to protect the gut mechanical and immune barriers.