Objective To compare the effect and safety of Jieyu Huatan Anshen Formule（Formula for relieving stagnation

dissolving phlegm and calming the mind） combined with risperidone and risperidone used singly in the treatment of schizophrenia.Methods Totally the 100 schizophrenia patients were randomized into a control group（n=50）

treated with risperidone

and a study group（n=50）

treated by Jieyu Huatan Anshen Formula combined with the half dosage of risperidone.The observation lasted 8 weeks.The therapeutic effect and safety were evaluated by the positive and negative syndrome scale（PANSS）

clinical global impression（CGI）

and treatment emergent symptom scale（TESS）.Results After treatment

the PANSS total scores and the factor scores of both groups were significantly decreased（P<0.01）.According to the rate of PANSS total scores subtraction

total effective rate of the study group was 60% and of the control group 58%

without sifnificant difference in both groups（P>0.05）.The in-group comparison of CGI effect showed a significant difference（P<0.01） in both groups

while the between-group comparison showed no significant difference（P>0.05）.The incidence of side effect of the study group and the control control group was 18% and 52% respectively

there exsisted a significant difference（P<0.01）.Conclusion Jieyu Huatan Anshen Formula combined with risperidone is effective and safe in the treatment of schizophrenia.