Objective To investigate the possible mechanism of Gongqing Granule（Granule for Clearing the Uterus） on shortening the duration of vaginal bleeding after medical abortion.Methods The 120 unwanted pregnancy women within 49d of intrauterine gestation were randomly divided into three groups.Gongqing Granule combined with mifepristone and misoprostol was administered orally in Group A（treatment group）.Qianzhi Capsule combined with mifepristone and misoprostol was administered orally to Group B（control group）

and only mifepristone plus misoprostol was administered orally to Group C（blank group）.Other 40 women（Group D

induced abortion group）

were treated with vacuum aspiration for abortion.Chorionic villi and decidual tissue were collected and expression of Bax and Bcl-2 were detected by immunohistochemical method and Bax mRNA and Bcl-2 mRNA by situ hybridization.Results The expression of Bax

Bcl-2

Bax mRNA and Bcl-2 mRNA was found in all groups.The expression of Bax and Bax mRNA in the treatment group was higher than those in the control group

then the blank group

and then induced abortion group.While the expression of Bcl-2 and Bcl-2 mRNA of the treatment group was lower than those in the control group

then the blank group

and then induced abortion group（P<0.05 or P <0.01）.And the effect on decidual apoptosis gene was especially significant in the treatment group.Conclusion Gongqing Granule can enhance the expression of Bax and decrease the expression of Bcl-2 to promote the apoptosis and reduce the decidual residue.This might be one of the mechanisms of Gongqing Granule in shortening the uterine bleeding after medical abortion.