WANG Liping, CHEN Jian, ZHUANG Yongze, et al. Correlation between Blood-stasis Syndrome and Pathological Changes in IgA Nephropathy Patients[J]. Journal of Traditional Chinese Medicine2009, 50(7): 635-638.
WANG Liping, CHEN Jian, ZHUANG Yongze, et al. Correlation between Blood-stasis Syndrome and Pathological Changes in IgA Nephropathy Patients[J]. Journal of Traditional Chinese Medicine2009, 50(7): 635-638.DOI: 10.13288/j.11-2166/r.2009.07.024.
Objective To observe the relation between blood-stasis syndrome(BSS) and clinical pathology in IgA nephropathy patients.Methods BSS of IgA nephropathy patients was scored.According to the scores
BSS was of the mild type and the serious type.The clinicopathological materials of 42 BSS patients and 73 patients with non blood-stasis syndrome were analyzed.Results The BSS patients were often accompanied with renal failure and BSS was seen mostly in females.The incidence of renal failure in severe BSS was higher than that in mild cases.Lee’s grade in BSS group was higher than that in non BSS group(P<0.01)
and Lee’s grade in severe BSS was more serious than that in mild BSS(P<0.01).The scores or ratio of renal tubule atrophy of BSS group were significantly higher than those of non BSS group.The Katafichi scores of severe BSS
scores of glomerulus and tubular interstitial lesions were significantly higher than those of mild BSS(P<0.01).The deposite of fibrinogen-related antigen(FRA) in renal tissues of BSS group was significantly stronger than that in non BSS group(P<0.05)
and the deposite of FRA in renal tissues of severe BSS was significantly stronger than that of non BSS(P<0.01).Conclusion BSS of IgA nephropathy and its degree are correlated with renal pathological changes.The more scores of BSS
the more severity of pathological lesion.The severity of BSS might be an important influencing factor on judging the severity of IgA nephropathy.