Objective To observe the specificity of acupoint and acupuncture in the mechanism of brain-hemodynamics on the model rats with middle cerebral artery obstruction（MCAO）.Methods The MCAO rats were divided into Renzhong（DU26） group

Neiguan（PC6） group

non-acupoint group

non-acupuncture group and model group

12 rats in each group.And a normal group as well as a sham-operation group were set as control.Renzhong group

Neiguan group

and non-acupoint group were treated with acupuncture in the frequency of 3 times/second for 5 seconds.Then

the effect was observed with the indices of cerebral blood flow（CBF）

cerebral capillary caliber and the quantity of cerebral capillary under the light microscope.Results Compared with non-acupuncture group

in the three acupuncture-treated group

the quantity of CBF and cerebral capillary were increased with significant difference（P<0.05）

while the cerebral capillary caliber had the tendency of contraction（P>0.05）

indicating that acupuncture could improve pathologic state of brain-hemodynamics of MCAO rats obviously.Of the three acupuncture groups

the CBF increase was more obviously in Renzhong and Neiguan groups than in non-acupoint group

mainly manifested in slightly cerebral capillary caliber extending（P<0.05）

meanwhile the quantity of cerebral capillary in Renzhong group increased（P<0.05）.Renzhong was better than Neiguan in promoting the production of cerebral capillaries.Conclusion Acu-points acupuncture are more effective than non-acupoint acupuncture in the improvement of brain-hemodynamics on rats with MCAO

and different acupoints have different effects through their specificity.