Objective To study the mechanisms of immunoregulation of Penning Granule（Granules for pelvic inflammation）.Methods The model rats of pelvic inflammation（PI） caused by mixed bacteria were established to observe the influence of different dosages of Penning Granule on serum interleukin 2（IL-2）

soluble interleukin 2 receptor（SIL-2R）

interleukin 6（IL-6）

tumor necrosis factor α（TNF-α）

and levels of immunoglobulin IgM

IgG

and IgA

the result of which was compared with those of Gentamicin and Kangfu Xiaoyan Shuan（Rectal suppository for women with PI）.Results Compared with the model group

the levels of IL-2

IgM

IgG

and IgA of all other groups were increased and SIL-2R

IL-6 and TNF-α decreased（P<0.05 or P<0.01）.The effect of high dosage group was better than those of the two control groups（Gentamicin and Kangfu Xiaoyan Shuan） with a significant difference（P<0.05） and close to the blank control group（P>0.05）.Conclusion Penning Granule can significantly improve the humoral immunologic function of pelvic inflammation rats.This is maybe one of its functional mechanisms in treatment of PI.