Objective To investigate the characteristics of herbal compatibility in Fuzheng Huayu Recipe（Recipe to reinforce the anti-pathogenic qi and dissolve stasis） against pulmonary fibrosis in rats.Methods The pulmonary fibrosis models were made by intratracheal injection of bleomycin（BLM） in male SD rats

and successful models were randomly divided into 16 groups according to orthogonal design.A normal control group was established as well.Changes in body weight and lung coefficient

inflammation and collagen deposition of lung tissues were observed

the hydroxyproline（Hyp） content was assayed

the SOD activity and MDA content were measured.Results Compared with the normal control group

the model groups had pulmonary alveolar wall destroyed with inflammatory cells infiltration and collagen deposition

and lung coefficient

lung Hyp and MDA contents increased

but SOD activity decreased.For decreasing Hyp content

the main effective herb is Gynostemma Pentaphyllammak（Jiaogulan）

secondly is Radix Salvia Miltiorrhiza（Danshen） and Semen Persicae（Taoren）

and Cordyceps（Dongchongxiacao） and Fructus Schisandrae Chinensis（Wuweizi） had the combinational effect to some extent.For improving SOD activity

the main effective herbs are Cordyceps Extract and Radix Salvia Miltiorrhiza.While Cordyceps and Fructus Schisandrae Chinensis had the obvious combinational effect.For decreasing MDA content

Gynostemma Pentaphyllammak had remarkably action

Radix Salvia Miltiorrhiza and Semen Persicae

Cordyceps and Radix Salvia Miltiorrhiza

Radix Salvia Miltiorrhiza and Fructus Schisandrae Chinensis had the combinational effects.Conclusion The main effective herbs of Fuzheng Huayu Recipe against pulmonary fibrosis in rats are Gynostemma Pentaphyllammak

Radix Salvia Miltiorrhiza

and Cordyceps.Among them

Gynostemma Pentaphyllammak plays the pivot role in inhibiting lung collagen production

Cordyceps and Radix Salvia Miltiorrhiza prominently protect rats from peroxidative injury.