Objective To observe the protective effect of Jiangzhi Fugan Decoction（Decoction for lipid-lowering and recovery of hepatic function） on the hepatic function in rats with non-alcohol fatty liver induced by high fat feeding.Methods Rat models with non-alcohol fatty liver were established by feeding high fat food.They were treated with Jiangzhi Fugan Decoction for 12 weeks.Then

the body weight and liver wet weight were measured to analyze the liver index

the pathological examination of liver tissues was performed under a microscope by HE staining

the biochemical indices of liver function and blood lipid were measured

and the level of IL-1α in hepatic tissue was detected by immunohistochemical method.Results The liver index

serum levels of alanine transaminase（ALT）

aspartic transaminase（AST）

triglyceride（TG）

low density lipoprotein cholesterol（LDL-C）

and hepatic tissue TG decreased in Jiangzhi Fugan Decoction group（P<0.05 or P<0.01） as compared with those of the model group

and immunohistochemical examination showed decrease of IL-1α expression in the hepatic tissue as well（P<0.05）.Conclusion Jiangzhi Fugan Decoction is effective in improving the pathological changes in hepatic tissues and steatosis

at the same time

in decreasing IL-1α expression.This is might be its mechanism in treating non-alcohol fatty liver induced by high fat feeding in rats.