Objective To observe the therapeutic effect of sequential therapy of activating blood circulation to dissolve blood stasis on rheumatoid arthritis（RA） patients and the improvement of blood stasis after treatment.Methods Sixty RA patients were randomized into control group and treatment group with 30 ones in each.The control group was treated by the routine way of western medicine and the treatment group by the sequential therapy in addition to western medicine.The course of treatment was 6 months in total.Changes in the symptoms of morning stiffness

arthralgia

swelling

skin color

subcutaneous nodule

tongue and pulse before and after treatment were observed and the experimental indices including erythrocyte sedimentation rate（ESR）

C reaction protein（CRP）

rheumatoid factor（RF）

Fibrinogen（Fg） and vascular endothelial growth factor（VEGF） were evaluated.Results Although the therapeutic effect of two groups turned out to be the same

the syndrome relief of the treatment group showed a better outcome（P<0.05）.The treatment group also showed better results on improvement of morning stiffness and down-regulation of ESR

CRP

RF

Fg and VEGF level（P<0.05）.Conclusion The sequential therapy can effectively improve the blood stasis state of RA patients and down-regulate the serum level of VEGF.Using sequential therapy of activating blood circulation to dissolve blood stasis might prevent RA aggravation.