Objective To observe the relevant factor of heat-blood stasis syndrome with renal pathological changes and local coagulation and fibrinolysis in patients with lupus nephritis（LN）.Methods Thirty LN patients with heat-blood stasis syndrome and 30 LN patients without heat-blood stasis syndrome were observed with electron microscope and immunohistochemical method for the analysis on renal pathological classification

renal activity index（AI）

chronic index（CI）

renal tissue fibrinogen-related antigen（FRA）

tissue plasminogen activator（tPA）

and plasminogen activator inhibitor-1（PAI-1） for comparison.Results There was no correlation between heat-blood stasis syndrome and renal pathological changes;renal AI of heat-blood stasis syndrome group was significantly higher than that of non-heat-blood stasis syndrome group（P<0.01）;the FRA deposition of heat-blood stasis syndrome group was significantly stronger than that of non-heat-blood stasis syndrome group（P<0.05）;the average scores of positive intensity of tPA and PAI-1 of heat-blood stasis syndrome group were significantly higher than those of non-heat-blood stasis syndrome group（P<0.05）.Conclusion The heat-blood stasis syndrome in LN patients correlates with the acitity of renal pathological changes

high local coagulation and low fibrinolysis.