Objective To observe the interventional effect of Wenxin Granule （Granule for calming the mind） on the physical constitution of qi deficiency

yin deficiency and both qi and yin deficiency type in perimenopausal women.Methods Of the 124 perimenopausal women

30 were diagnosed constitutionally qi deficiency

58 were diagnosed constitutionally yin deficiency

and 36 were diagnosed constitutionally qi and yin deficiency.Each of the constitution group was subdivided into treatment and control group

with 15 cases in each in qi deficiency constitution group;30 cases in the treatment group of yin deficiency constitution group while 28 in the control group;and 18 cases in each in qi and yin deficiency constitution group.All the treatment groups were administered Wenxin Granule and the control groups were without any treatment.Before and 12 weeks after treatment

the changes in constitution scores and sex hormone levels were compared.Results Comparing with before treatment and the control groups

the constitution scores of treatment groups after treatment were significantly reduced （P<0.05 or P<0.01）

while the sex hormone levels were not significantly changed （P>0.05）.Conclusion Wenxin Granule can improve the qi deficiency

yin deficiency

qi and yin deficiency constitution of perimenopausal women

effective to help them pass through perimenopausal period smoothly.