Objective To observed the effect of Shendi Jiangtang Granule （Granule for reducing glucos）

on insulin sensitivity in insulin resistance accompanied hypertension model rats and its mechanism.Methods Six-week-old male Sprague-Dawley rats were divided into blank group

model group and Chinese medicine group. The blank group were fed with normal rat chow

and the others were fed with fructose-rich chow （FFR）. The Chinese medicine group was given Shendi Jiangtang Granule （3.24 g/kg/day）. Systolic blood pressure was measured weekly for 6 weeks. Then the euglycemic hyperinsulinemic glucose clamp technique was performed to estimate insulin sensitivity （M value）. At the end of the glucose clamp

the soleus and extensor digitorum longus （EDL） muscles were dissected out for determination of the role of tumor necrosis factor-α（TNF-α） by an ELISA assay.Results Treatment with Shendi Jiangtang Granule significantly improved the M value in FFR rats （P<0.01）;and siginificanty lowered TNF-α levels in the skeletal muscles（P<0.01）.Conclusion Chinese medicine Shendi Jiangtang Granule may improve insulin resistance

the effect might be related to reducing TNF-α in the skeletal muscles in hypertensive and insulin resistant fructose-fed rats.