Objective To observe the therapeutic effect of Shugan Jianpi Recipe （Recipe to soothe the liver and strengthen the spleen） plus Lamivudine on the liver stagnation and spleen deficiency syndrome of chronic hepatitis B.Methods Of the 180 patients with chronic hepatits B

62 patients in the treatment group were prescribed Shugan Jianpi Recipe plus Lamivudine

58 patients in the control group I were administered Lamivudine only

and 60 patients in the control group II were given Shugan Jianpi Recipe only. All the three groups were treated for 12 months and followed for 6 months. The changes in the liver functions

HBV DNA quantity

HBeAg

the incidence of YMDD

clinical symptoms

and the total effective rate were observed.Results After treatment for 12 months

in the treatment group

the improvement in ALT was more significant than that in the control group I （P<0.05）; the HBeAg negative rate in the sixth-month follow-up was significantly higher than that of the two control groups （P<0.05）; the HBV DNA negative rate in the sixth and twelfth-month treatment and the sixth-month follow-up was significantly higher than that of the two control groups （P<0.05）. When the follow-up finished

YMDD positive rate in the HBV DNA positive patients was lower than that of the control group I （P<0.05）. The total effective rate of the treatment group

the control group I and II was 85.5%

65.5%

and 70.0% respectively

the difference was significant （P<0.05）.Conclusion Shugan Jianpi Recipe plus Lamivudine is effective for the liver stagnation and spleen deficiency syndrome of chronic hepatitis B in restoring the liver functions

improving the clinical symptoms

enhancing the anti-virus effect

and reducing the incidence of Lamivudine resistance.