YANG Shaojun1, LIU Jianhong2, WANG Yali1, et al. Effect of Pingwei Xiaodao Capsule on Gastric Motility of Functional Dyspepsia Model Rats[J]. Journal of Traditional Chinese Medicine2010, 51(6): 551-553.
YANG Shaojun1, LIU Jianhong2, WANG Yali1, et al. Effect of Pingwei Xiaodao Capsule on Gastric Motility of Functional Dyspepsia Model Rats[J]. Journal of Traditional Chinese Medicine2010, 51(6): 551-553.DOI: 10.13288/j.11-2166/r.2010.06.001.
Objective To observe the effect and mechanism of Pingwei Xiaodao Capsule (Capsule for functional dyspepsia) on the gastric motility of functional dyspepsia (FD) model rats.Methods Totally 60 wistar rats were randomized into a blank control group (normal group)
model group
domperidone group
Pingwei Xiaodao Capsule large
medium
and small dosage groups.Except for the normal group
the rats of all other groups were irritated by clamping tails for making FD models.Then
the treatment was given for 7 days.The comparative observation was carried out on the gastric interdigestive myoelectric complex (IMC)
slow wave frequency variation coefficient
abnormal rhythm index
and gastric emptying rate of all groups.Results Compared with the model group
the IMC period of domperidone group and all Pingwei Xiaodao Capsule groups was shortened
phase Ⅲ prolonged
incidence of phase Ⅲ increased(P<0.05 or P<0.01)
slow wave frequency variation coefficient and abnormal rhythm index significantly improved (P<0.05 or P<0.01)
and gastric emptying rate increased (P<0.05 or P<0.01).On increase of the phase Ⅲ incidence
the effect of Pingwei Xiaodao Capsule large dosage group was better than that of the domperidone group and the Pingwei Xiaodao Capsule small dosage group (P<0.05).On improvement of slow wave frequency variation coefficient and increase of gastric emptying rate
the effect of Pingwei Xiaodao Capsule large dosage group was better than that of the small dosage group (P<0.05).Conclusion Pingwei Xiaodao Capsule can strengthen the gastric myoelectric activities
promote the gastric emptying and improve the abnormal gastric electric rhythm.The better effect was found in the large dosage group.