Objective To observe the influence of Jianpi Tiaogan Wenshen Recipe （Recipe for strengthening the spleen

regulating the liver

and warming the kidney） on the clinical symptoms and quality of life of the patients with diarrhea-predominant irritable bowel syndrome （D-IBS）.Methods A prospective

randomize-controlled trial was conducted.The 80 D-IBS patients were equally randomized into 2 groups.The treatment group was administered Jianpi Tiaogan Wenshen Recipe and the control group was prescribed pinaverium bromide tablet for 4 weeks.Before and after treatment

the symptoms of abdominal pain or discomfort were observed and recorded

36-item short-form health survey （SF-36） and IBS quality of life （IBS-QOL） were adopted to evaluate the quality of life of the patients.The cured and remarkably effective cases were followed up four weeks after stopping medicine.Results The difference in in-group and between-group comparison in the symptoms of abdominal pain or discomfort and abdominal distention before and after treatment was not significant.The difference in the scores of mucus stool of two groups after treatment was significant （P<0.05）

the treatment group was better than the control group.The curative rate of the treatment group and the control group was 24.3% and 19.4% respectively

and the total effective rate was 81.1% and 80.6% respectively

without significant difference（P>0.05）.The long-term effect:there were 4 and 12 cases relapsed or aggravated in the treatment group and control group respectively

the difference was significant （P<0.01）.Quality of life:the treatment group was better than the control group in improving the somato pain

mental health

social functioning

dysphoria

and interpersonal relationship （P<0.05）.Conclusion Jianpi Tiaogan Wenshen Recipe improves not only the symptoms but also the quality of life of the D-IBS patients.