Objective To observe the effect of Jingujian Granule （Granule for strengthening the bones） No.1

2

and 3 on primary osteoporosis in the TCM syndromes of liver-kidney deficiency

both spleen and kidney deficiency

and spleen and kidney deficiency accompanied with blood stasis

and the influence on the bone metabolism indices.Methods Totally 210 primary osteoporosis cases were differentiated according to the TCM differentiation and administered Jingujian Granule No.1

2

3 or Caltrate D accordingly.The observation was carried out for 3 months on the improvement of clinical symptoms

changes in bone mineral density and bone metabolism indices

and safety indices.Results The total effective rate of Jingujian Granule No.1

2

and 3 was 89.92%

while that of Caltrate D was 33.3% （P<0.01）.The Chinese herbal medicine was better than Caltrat D in improving the symptoms （P<0.05）.Jingujian Granule had the functions to decrease acid phosphatase and osteoprotegerin

and increase alkaline phosphatase

estradiol

osteocalcin

and calcitonin

being more effective than Caltrate D （P<0.05 or P<0.01）.Conclusion Jingujian Granule is better in effect than Caltrate D for primary osteoporosis.