Objective To observe the effect of Shengxian Decoction （Decoction for lifting the depressed organs） in the treatment of 38 patients with obstructive sleep apnea hypopnea syndrome （OSAHS） in the TCM syndrome of qi deficiency of the lung and spleen. Methods Totally 68 patients were randomized into a control group （30 cases） treated by Duxil for oral taking and a treatment group （38 cases） treated by Duxil and Shengxian Decoction for 10 days. The changes in the symptom scores of both groups after treatment were observed. The polysomnogram （PSG） was applied before and after treatment to record the total sleep time

hypopnea total time

and average heart rate to calculate the times when oxygen saturation was less than 90% in each hour sleep time

the total continuous time when oxygen saturation was less than 90% in the whole night

apnea-hypopnea index （AHI）

and hypopnea index （HI）. Results After treatment

the main symptoms in the treatment group were significantly improved （P<0.05 or P<0.01）

the symptoms in the control group were also significantly improved except poor appetite

loose stools

white tongue coating

and soft thready weak pulse （P<0.05 or P<0.01）. The improvement of the treatment group was more significant than that of the control group （P<0.05）. Except the average heart rate

the main PSG indices of the treatment group were all improved than before treatment （P<0.05 or P<0.01）

while in the control group

only the times when oxygen saturation was less than 90% in each hour sleep time and the total continuous time when oxygen saturation was less than 90% in the whole night were improved than before treatment （P<0.05 or P<0.01）. To compare the two groups

the prolonged sleep time

HI

hypopnea total time

and the decreased times when oxygen saturation was less than 90% in each hour sleep time and the decreased total continuous time when oxygen saturation was less than 90% in the whole night of the treatment group were better than those of the control group （P<0.05）. Conclusion Shengxian Decoction is effective for OSAHS in the TCM syndrome of qi deficiency of the lung and spleen.