Objective To study on the uric metabolites of coronary heart disease（CHD）patients with heart blood stasis syndrome in TCM and analyze comprehensively the metabolic pathway of heart blood stasis syndrome.Methods ①GC-MS was adopted to detect the uric metabolites of CHD patients with heart blood stasis syndrome

CHD patients without heart blood stasis syndrome

and healthy people.The principal component analysis（PCA）and partial least squares（PLS）analysis were done to study the changes of uric metabolites of different groups.②The metabolic pathway of heart blood stasis syndrome of CHD was analyzed comprehensively.Results ①PCA:The principal component scores of the three groups were distributed in three regions in the oval score graph respectively.Of the 19 uric metabolites

the contents of glycerol

oleamide

glucose

and acetone were increased and those of hippuric acid and xylitol were decreased.② PLS:The result of healthy people was far from those of CHD patients with and without heart blood stasis syndrome

the latter two groups tended to be of a same category.It could be seen from the standardized PLS coefficient graph that there was a positive correlation between heart blood stasis syndrome and the level of glycerol and oleamide and a negative correlation with the level of hippuric acid and xylitol.According to VIP value

all variables were arranged in an order of glucose

glycerol

xylitol

hippuric acid

oleamide

and acetone.③Variability:In the uric metabolites of CHD patients

the content of glucose

glycerol

oleamide

and acetone was increased

especially in those with heart blood stasis（P<0.01）.Of them

there also existed a significant different in glycerol

oleamide and acetone of those CHD patients without heart blood stasis and healthy people（P<0.01）.Adonitol and hippuric acid in the CHD patients with and without blood stasis syndrome were both decreased

especially in those with blood stasis syndrome（P<0.01）.Conclusion ① The uric metabolites of CHD patients with heart blood stasis are glucose

glycerol

xylitol

hippuric acid

oleamide

and acetone.② From the uric metabolites

it is reflected that the metabolic pathway of heart blood stasis syndrome is related with the disorders of lipid metabolism and the stress

as well as the dysfunctions of kidney and liver.