Objective To investigate the effect of Jinmaitong Capsule（Herbal capsule for removing obstruction of channels）on diabetic peripheral neuropathy and its machanism.Methods The Jinmaitong Capsule and Neurotropin medicated serum was prepared respectively according to the 15 times of adult dosage for Wistar rats.In the experiment

the grouping was the blank control group（without cells added）

normal control group（with normal rat serum added）

high glucose group（with glucose added）

Jinmaitong group（with the Jinmaitong Capsule medicated serum and normal rat serum added）

and neurotropin group（with the neurotropin medicated serum added）.Except the blank control group and normal control group

the 50 mmol/L glucose was added to all other groups respectively to make high glucose Schwann cell models.The expression of ciliary neurotrophic factor（CNTF）and CNTF-mRNA was detected by SABC immunohistochemistry method and real-time fluorogenetic quantitative PCR respectively.Results Compared with the normal control group

the CNTF and CNTF-mRNA expression in the high glucose group

Jinmaitong group

and neurotropin group was lowered（P<0.01）.Compared with the high glucose group

the CNTF-mRNA and CNTF expression of the Jinmaitong group and neurotropin group was increased（P<0.01）and the CNTF-mRNA expression in the Jinmaitong group was higher than that in the neurotropin group（P<0.05）.Conclusion Jinmaitong Capsule can up-regulate the expression of CNTF and CNTF-mRNA of rat Schwann Cells cultured in high glucose medium

so as to improve the diabetic peripheral neuropathy.