Objective To evaluate the effect of TCM comprehensive intervention on the mild cognitive impairment caused by leukoaraiosis.Methods Totally 78 patients with mild cognitive impairment due to leukoaraiosis were randomized into the TCM comprehensive intervention group and control group with 39 in each.The control group was treated with the regulation of life style and treatment of basic diseases

based on which

the intervention group was treated with Compound Congrong Yizhi Capsule （Herbal capsule mainly containing cistanche for cognitive impairment）

4 capsules each time

3 times a day

and acupoint massage before sleep in the evening everyday.The treatment lasted for 90 days.The scores of 68 clinical symptoms

Montreal Cognitive Assessment （MoCA）

and Activities of Daily Living （ADL） were used to evaluate the effect.Results After treatment

the patients in the TCM comprehensive intervention group were greatly improved in the symptoms including headache

heaviness in the head

dizziness

insomnia

restlessness

hot temper

listlessness

fatigue

palpitation

soreness and weakness in the lumbus and legs

heaviness of the body

cold extremities

thirst with desire to drink

tastelessness

cough with phlegm

shortness of breath

fullness in the chest

sighs

and hot sensation in palms and soles

with significant difference （P<0.05 or P<0.01）.The MoCA score was increased

ADL score decreased （P<0.05 or P<0.01）

and the score of MoCA visual space

executive function

nominating

abstract thinking

and the sub-items of delaying memory was significantly increased

with significant difference as compared with those before treatment （P<0.05 or P<0.01）.The improvement of MoCA and ADL scores in the intervention group was more significant than that in the control group.Conclusion The TCM comprehensive intervention can improve the cognitive functions of those patients who are with cognitive impairment caused by leukoaraiosis and its induced symptoms to improve the daily living activities.