Objective To observe the clinical effect of Guo’s therapy on the moderate osteofluorosis. Methods Totally 120 patients with moderate osteofluorosis were randomized into treatment group and control group with 60 in each. The treatment group received the basic treatment and Guo’s therapy （herbal Strychnos as the main ingredient） while the control was given the basic treatment and placebo. Both groups were treated for 12 weeks and followed up for 24 weeks. Before treatment and 1

2

3

4

8

12

24 and 36 weeks after treatment

the patients were evaluated acording to pain visual analogue scale （VAS）

morning stiffness

numbness

tightness sensation

and convulsion by a third part. Results After two weeks of treatment

the VAS score of both groups was significantly decreased （P<0.01）; after four weeks of treatment

there was significant difference in VAS between the two groups （P<0.01）; two weeks after treatment

the disappearance rate of tightness sensation in the treatment group was higher than that in the control group （P<0.05）; eight weeks after treatment

the disappearance rate of morning stiffness and convulsion in the treatment group was higher than those in the control group （P<0.05）. However

the disappearance rate of numbness in the two groups was not significantly different （P>0.05）. Conclusion Guo’s therapy taking the herbal Strychnos as the main ingredient is effective in improving the symptoms including pain

morning stiffness

numbness

tightness sensation

and convulsion of the patients. It is a good treatment for moderate osteofluorosis.