Objective To investigate the short term effect and safety of Qingre Huoxue Recipe （Recipe for clearing heat and activating blood） on the coronary heart disease patients with acute myocardial infarction. Methods Sixty patients were randomized into treatment group and control group. The former received a routine western medicine treatment plus Qingre Huoxue Recipe

one dose per day

while the latter received a routine western medicine treatment only

for a course of 30 days. After the treatment was finished

symptom score

C-reactive protein （CRP）

white blood cells （WBC） count

neutrophil （NEU） percentage

heart rate

blood pressure

incidence of adverse events

and incidence of endpoint events at the end of 1-month and 6-month follow-up were compared between groups. Results There existed a significant statistical difference in the symptom scores

CRP level

WBC count

and NEU percentage in the two groups before and after treatment （P<0.05 or P<0.01）. Conclusion Qingre Huoxue Recipe is good and safe in improving the score of heat syndromes and lowering the inflammatory factors in the short term treatment of acute myocardial infarction of coronary heart disease patients.