Objective To discuss the inhibitory effect and mechanism of Bazhen Decoction （Eight Precious Ingredients Decoction） for the angiogenesis in breast cancer patients. Methods Ninety breast cancer patients were randomized into 3 groups:Group Ⅰ （chemotherapy applied before operation）

Group Ⅱ （Bazhen Decoction and chemotherapy applied before operation）

and Group Ⅲ （control group

not treated before operation）. Short term effect

serum vascular endothelia growth factor （s-VEGF） before and after treatment

tumor micro-vessel density （MVD） and VEGF protein after treatment were observed. Results Compared with group Ⅲ

the short term total effective rate was significantly increased （P<0.05）

the progress rate decreased （P<0.01） in group Ⅰ and Ⅱ. After treatment

s-VEGF in Group Ⅱ was significantly decreased （P<0.05） and lower than that of the Group Ⅲ （P<0.05）. Before treatment the concentration of s-VEGF of all patients was in positive correlation with the size of tumor

lymphatic metastasis

and TNM staging. In Group Ⅱ

the tumor MVD and VEGF protein were both significantly decreased in comparing with Group Ⅲ （P<0.05）. After treatment there was a positive correlation between the s-VEGF and the tumor VEGF as well as MVD. Conclusion Bazhen Decoction can inhibit the angiogenesis in breast cancer

and the mechanism may be concerned with its inhibitory function on VEGF expression of breast cancer tissues.