Objective To study the effect of acupuncture combined with Propofol in anesthesia on preventing the stress reaction in gastroscopy.Methods Totally 135 cases underwent gastroscopy were randomized into an experiment group and two control groups with 45 cases in each. The experiment group was treated by acupuncture at Hegu （LI 4）

Neiguan （PC 6）

and Zusanli （ST 36） in combined with venous administration of Propofol for anesthesia; while the control group Ⅰ was applied venous administration of Propofol combined with Fentanyl Citrate

and the control group Ⅱ was given venous administration of Propofol only. The changes of blood pressure （BP）

heart rate （HR）

respiration rate （RR）

and oxyhemoglobin saturation （SPO2） were investigated in all three groups. The amount of Propofol used

lasting time of gastroscopy

and awaking time of patient were recorded. The stress reaction was observed to compare the effect of prevention.Results In the experiment group

BP

HR

RR

and SPO2 were more stable than those in the control groups （P<0.05 or P<0.01）. The amount of Propofol used

lasting time of gastroscopy

and awaking time of patient of the experimental group were decreased as compared with those in the control group Ⅱ

and the effect on preventing the stress response was better than that of the control group Ⅱ （P<0.05 or P<0.01）

but there was no statistical significance in the above-mentioned indices as compared with the control group Ⅰ （P>0.05）.Conclusion Acupuncture combined with Propofol for anesthesia is an effective method of preventing the stress response in gastroscopy

having the advantage of less impact on respiration and circulation systems of patient

beneficial to the stable physiological condition of patient.