清胰化积中药联合动脉灌注化疗及放疗治疗无法手术切除胰腺癌患者41例临床研究

沈晔华; 刘鲁明; 朱晓燕; 孟志强; 陈震; 林均华; 周振华; 陈颢; 王琨; 于尔辛

doi:10.13288/j.11-2166/r.2010.12.040

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清胰化积中药联合动脉灌注化疗及放疗治疗无法手术切除胰腺癌患者41例临床研究

临床研究 | 更新时间：2021-11-17

- 清胰化积中药联合动脉灌注化疗及放疗治疗无法手术切除胰腺癌患者41例临床研究
- A Clinical Trial on the Effect of Qingyi Huaji Herbal Decoction Combined with Transcatheter Arterial Chemotherapy and Radiotherapy for Inoperable Pancreatic Cancer
- 中医杂志 2010年51卷第12期页码：1093-1096
- 作者机构：
  
  1. 复旦大学附属肿瘤医院中西医结合科
  2. 复旦大学上海医学院肿瘤学系
- 作者简介：
- 基金信息：
  
  上海市科技发展基金资助项目（02DZ19106）
- DOI：10.13288/j.11-2166/r.2010.12.040
  中图分类号： R735.9
- 纸质出版：2010
- 稿件说明：
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[1]沈晔华,刘鲁明,朱晓燕,孟志强,陈震,林均华,周振华,陈颢,王琨,于尔辛.清胰化积中药联合动脉灌注化疗及放疗治疗无法手术切除胰腺癌患者41例临床研究[J].中医杂志,2010,51(12):1093-1096+1100.

SHEN Yehua, LIU Luming, ZHU Xiaoyan, et al. A Clinical Trial on the Effect of Qingyi Huaji Herbal Decoction Combined with Transcatheter Arterial Chemotherapy and Radiotherapy for Inoperable Pancreatic Cancer[J]. Journal of Traditional Chinese Medicine2010, 51(12): 1093-1096.
[1]沈晔华,刘鲁明,朱晓燕,孟志强,陈震,林均华,周振华,陈颢,王琨,于尔辛.清胰化积中药联合动脉灌注化疗及放疗治疗无法手术切除胰腺癌患者41例临床研究[J].中医杂志,2010,51(12):1093-1096+1100. DOI： 10.13288/j.11-2166/r.2010.12.040.

SHEN Yehua, LIU Luming, ZHU Xiaoyan, et al. A Clinical Trial on the Effect of Qingyi Huaji Herbal Decoction Combined with Transcatheter Arterial Chemotherapy and Radiotherapy for Inoperable Pancreatic Cancer[J]. Journal of Traditional Chinese Medicine2010, 51(12): 1093-1096. DOI： 10.13288/j.11-2166/r.2010.12.040.

摘要

目的观察清胰化积中药联合动脉灌注化疗（TAC）及胰腺肿瘤放疗治疗手术无法切除的局部晚期或转移性胰腺癌的疗效及不良反应。方法共80例胰腺癌患者纳入本研究

在接受TAC（吉西他滨+顺铂或奥沙利铂）及胰腺肿瘤放疗（36～40Gy/1.8～2Gy）的基础上

随机分为中药组41例和对照组39例

中药组给予清胰化积中药

连服8周。比较两组间的客观疗效、生存情况及不良反应等。结果中药组中位生存期5.1个月

对照组4.2个月

一年生存率两组分别为9.8%和5.1%（P<0.05）。中药组部分缓解（PR）13.9%

稳定（SD）33.3%

进展（PD）52.8%;对照组PR0

SD36.1%

PD63.9%

组间比较无统计学意义。治疗相关不良反应两组间差异无统计学意义。结论清胰化积中药联合TAC及放疗可延长晚期胰腺癌患者生存期。

Abstract

Objective To observe the effect of Qingyi Huaji（clearing pancreas and dissolving stasis）herbal decoction combined with transcatheter arterial chemotherapy（TAC）and radiotherapy in the treatment of advanced or metastatic pancreatic cancer.Methods Totally 80 pancreatic cancer patients received TAC（gemcitabine and cisplatin or oxaliplatin）and radiotherapy 36～40 Gy/1.8～2.0 Gy and they were randomized into herbal group（41 cases）and control group（39 cases）.The herbal group was administered Qingyi Huaji herbal decoction

8 weeks in succession.Objective effect

survival

and treatment-related adverse reaction of the two groups were compared.Results In the herbal group the median survival time was 5.1 months and was 4.2 months in the control group

and one-year survival rate was 9.8% and 5.1% respectively in two groups（P<0.05）.PR

SD and PD of the herbal group was 13.9%

33.3% and 52.8% respectively

while PR

SD and PD of the control group was no significant difference between groups.The treatment-related adverse reaction of the two groups was without significant difference.Conclusion Qingyi Huaji herbal decoction in combination with TAC may prolong the survival time of patients with advanced pancreatic cancer.

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