Objective To investigate the effect of Erzhi Tiaojing Granules（Herbal granules for regulating menstruation） on the follicle quality in infertility patients with polycystic ovary syndrome（PCOS）.Methods Sixty PCOS patients were randomized into two groups

30 in each.Both groups were pretreated with ethinylestradiol and cyproterone acetate tablets for three circle.At the begining of the fourth circle

both groups were given clomifene citrate capsule and menotrophin for injection

while the treatment group was additionally given Erzhi Tiaojing Granules.After treatment

the improvement of kidney deficiency symptoms in the two groups was observed

the difference in pregnancy rate

blood flow of stroma of ovary

estradiol（E2）

luteinizing hormone（LH）

and the content of serum platelet activation factor（PAF） were compared to see their correlation with the follicle quality.Results The pregnancy rate of the treatment group and the control group was 36.7% and 26.7% respectively with no statistic difference between（P>0.05）.The improvement of the treatment group in kidney deficiency symptoms was significantly better than that of the control group（P<0.05）.The treatment group was superior in the improvement in blood flow of stroma of ovary and increase of E2 and content of PAF（P<0.05）.There was no statistical difference between groups in the improvement in LH（P>0.05）.Conclusion Erzhi Tiaojing Granules in combination with western drug is effective in improving the follicle quality and pregnancy rate of PCOS patients with kidney difficeincy in TCM.The mechanism of which is related to improving the endocrine system and blood flow of stroma of ovary

at the same time

to its effect on regulating the PAF production.