Objective To observe the effect of Bushen Zhuanggu Granules （Herbal granules for reinforcing kidney to strengthen bones） upon gonadal hormone and vasomotor symptoms of climacteric females. Methods Totally 582 postmenopausal outpatients were randomized into Chinese medicine group of 285 cases and western drug group of 297 cases. The Chinese medicine group was treated with Bushen Zhuanggu Granules and the western drug group was with premarin and provera. The main observed indices were blood fat including total cholesterol （TC）

triglyceride （TG）

high density lipoprotein cholesterol （HDL-C）

and low density lipoprotein cholesterol （LDL-C）

gonadal hormones including estradiol （E2）

follicle stimulating hormone （FSH）

and luteinizing hormone （LH）

and the changes in scores of symptoms and signs before and after treatment. Results There were 63 dropouts in the Chinese medicine group after a half-year’s treatment

and 94 dropouts in the western drug group

the difference between the two groups was significant （P<0.01）. The total effective rate of the Chinese medicine group was 82.87%

while that of the western drug group was 73.12%

there was significant difference between the two groups after treatment （P<0.05）. The total symptom score of both groups was significantly decreased after treatment （P<0.05 or P<0.01）

but the Chinese medicine group was superior to the western drug group （P<0.01）. Changes of gonadal hormone and blood fat of both groups after treatment was significant

showing a statistical difference （P<0.05）. Conclusion Bushen Zhuanggu Granules can effectively regulate gonadal hormone and blood fat in climacteric females

with a similar function of western estrogen replacement therapy

but without untoward effect.