Objective To study the effect of Bushen Huoxue Granule（Granule for reinforcing kidney and activating blood）on dopamine（DA）in Parkinson’s patients.Methods In the double-blinded clinical trial

sixty patients were randomized into two groups with 30 in each.The treatment group was treated with Bushen Huoxue Granule and the control group was with placebo

twice a day.Both groups were taking western medicine as basic treatment.The observation was carried out for 3 months.The follow-up was of 6 months after the treatment cause.Using encephalofluctuography（EFG）to measure the changes of DA in both groups at baseline time

3

6 and 9 months later to evaluate the effect of Bushen Huoxue Granule.Results In the control group

DA level decreased gradually after the treatment for 9 months

but there was no statistical difference（P>0.05）.In the treatment group

DA level increased in the treatment observation period and follow-up with statistical difference（P<0.05）.Conclusion The level of DA has being reduced along with the progress of PD.Bushen Huoxue Granule can increase the level of DA in the brain of PD patients with reliable effect.