Objective To compare the effect of the three classic formulas Yinchenhao Decoction（Decoction of Herba Artemisiae Scopariae）

Yichen Wuling Powder（Powder of Five Drugs with Poria added by Herba Artemisiae Scopariae）and Dachaihu Decoction（Major Bupleurum Decoction）on the liver and renal functions of rats with experimental extrahepatic cholestasis.Methods Common bile duct ligation in three segments was performed to establish the cholestasis models.One week after modeling

the intervention groups were respectively given Yinchenhao Decoction

Yinchen Wuling Powder and Dachaihu Decoction intragastrically everyday in dose of 1ml/100g body weight.The model group and sham operation groups were administered isometric normal saline.Rats were killed 3 weeks after modeling to detect the liver and renal functions.Results Compared with the sham operation group

ALB content in the model group was significantly decreased（P<0.05）

the content of TBiL

TBA

CHO

BUN

and the activity of ALT

AST

LDH

ALP and GGT were all significantly increased（P<0.05

P<0.01）.Compared with the model group

Yinchenhao Decoction

Yinchen Wuling Powder

and Dachaihu Decoction all could increase the content of ALB

and significantly decrease the content of TBiL and TBA

and the activity of ALT

AST

LDH

ALP and GGT（P<0.01）.Yinchenhao Decoction was significantly better than Yinchen Wuling Powder in decreasing TBiL content and ALP activity（P<0.05）.Yinchenhao Decoction was significantly better than Dachaihu Decoction in decreasing the activity of ALT

AST

LDH and GGT

and the content of TBA（P<0.01）.Conclusion Yinchenhao Decoction

Yinchen Wuling Powder and Dachaihu Decoction all can improve the changes of liver and renal functions of rats with extrahepatic choleasstis.The comprehensive effect of Yinchenhao Decoction is better.