Objective To observe the TCM syndromes of rat models of type 2 diabetes and discuss the syndrome evolution in different stages of disease. Methods Wistar rats

except for the normal control group

were fed with high-fat and high-sucrose diet for 4 weeks

and treated by intraperitoneal streptozotocin injections for model making. Those with successful model establishment were randomized into control group

Zengye Tang （fluid-increasing decoction） group

Shengmai San （pulse-restoring powder） group

and Shenqi Wan （renal-qi Pill） group. Each of them was subdivided randomly into Ⅰ

Ⅱ

and Ⅲ stage subgroups for herbal medicinal intervention at the time of 0w

4w

and 8w. After the medicinal intervention for four weeks in each stage

changes in blood sugar

blood fat

insulin

glucagons

and pathologic structure were observed. Results The effect of stage Ⅰ of Shenqi Wan group was better than that of other group. All indices of stage Ⅱ of Shengmai San group were improved significantly. The result of stage Ⅲ of Zengye Tang group was superior to that of the other groups

and the islet cells of Zengye Tang group were tending to normal

and without islet fibration. Conclusion Diabetes model made by this way is similar to the human type 2 diabetes. In its early stage （stage Ⅰ）

the syndorome is of both yin and yang deficiency; in its medium stage （stage Ⅱ）

the syndorome is of both qi and yin deficiency

and in its late stage （stage Ⅲ）

the syndorome is of yin deficiency.