Objective To observe the difference and dose-effect relationship of moxibustion with wheat grain sized cones at different dosages for regulating the blood fat in acute hyperlipemia rats. Methods The acute hyperlipemia rat models were made by intraperitoneal injection of yolk emulsion. Totally 72 SD rats were randomized into 6 groups:normal control group

hyperlipemia model group

medicinal treatment group

wheat grain sized 3-Cone moxibustion group

wheat grain sized 6-Cone moxibustion group

and wheat grain sized 9-Cone moxibustion group

12 rats in each group. The moxibustion groups were treated respectively with 3 cones

6 cones

and 9 cones each point per day at Shenque （CV8） and Housanli （ST36）. The medicinal treatment group was treated with Lovastatin suspension for gastric injection at the dosage of 10 mg/（kg·d）. The treatment lasted for 3 days. After treatment

we tested the serum total cholesterol （TC）

triglyceride （TG）

low density lipoprotein C （LDL-C）

and high density lipoprotein C （HDL-C）. Results In the hyperlipemia model group

the serum TC

TG

and LDL-C were all increased

while the HDL-C was decreased. Compared with the normal control group

there was statistical difference（P<0.01）. Compared with the hyperlipemia model group

the medicinal treatment group and the moxibustion groups could make the TC

TG

and LDL-C decreased and HDL-C increased with statistical difference （P<0.05 or P<0.01）. Of the moxibustion groups

the 6-Cone and 9-Cone groups were superior to the medicinal treatment group and 3-Cone moxibustion group in decreasing TG （P<0.01）. The 3-Cone moxibustion group and medicinal treatment group were better than the 6-Cone moxibustion group in increasing HDL-C （P<0.05 or P<0.01）. Conclusion The moxibustion with wheat grain sized cones at different dosages is all effective in regulating the blood fat in acute hyperlipemia rats. For decreasing TG

the effect of 6-Cone and 9-Cone is the best

and for increasing HDL-C

the effect of 3-Cone and the medicinal treatment is better.