Objective To observe the effect of transdermal penetration of Zhentong Songji Huoxue Recipe（Chinese herbal medicines for activating blood to stop pain）in the treatment of chronic lumbosacral and leg pain resulted from extravertebral soft tissue lesion.Methods The 120 patients were randomized into the treatment group and control group

60 cases in each group.Both of them were treated with Shuangli Atmospheric Pressure Sealed Equipment

and the treatment group was given Zhentong Songji Huoxue Recipe through hot-wet compression for transdermal penetration

while the control group was given normal saline through hot-wet compression for transdermal penetration.The treatment lasted for 40 minutes each time

once a day

14 days as one course.Before and one course after treatment

the effect of both groups was scored and compared with visual analog scale（VAS）and Oswestry disability index（ODI）for evaluation.Results After treatment

the VAS and ODI scores of both groups were significantly improved as compared with those of before treatment（P<0.05 or P<0.01）

but the improvement of the treatment group was more significant（P<0.01）.Conclusion The transdermal penetration of Zhentong Songji Huoxue Recipe is effective in the treatment of chronic lumbosacral and leg pain resulted from extravertebral soft tissue lesion.