Objective To observe the therapeutic effect of Huangqi Guizhi Wuwu Decoction（Decoction of Five Materials including Radix Astragali seu Hedysari and Ramulus Cinnamomi）in different dosages on diabetics with peripheral neuropathy（DPN）.Methods Sixty-eight DPN patients were randomized into treatment group and control group with 34 in each.Both groups were given the decoction based on routine methods.The control group was administered Huangqi Guizhi Wuwu Decoction in a dosage with 1 Liang as 9g

while the treatment group was given the Decoction in a dosage with 1 Liang as 15g.One dosage each day

8 weeks in succession.Before and after treatment

the liver and kidney functions and the changes of peroneal nerve conduction velocity（NCV）were examined respectively to determine the effect.Results The total effective rate of the treatment group was 91.2% and that of the control group was 70.5%

the difference was statistically significant（P<0.01）.The NCV of both groups was significantly improved after treatment with statistical difference（P<0.05）.The difference in two-group comparison was also statistically significant（P<0.05）.Before and after treatment

the patients of both groups didn’t have disturbance of liver and kidney functions and other untoward effect.Conclusion Huangqi Guizhi Wuwu Decoction in a dosage with 1 Liang as 15g can significantly enhance the therapeutic effect on DPN

better than that of the dosage with 1 Liang as 9g

and there is no obvious side effect in treatment.