Objective To observe the influence of New Xuefu Zhuyu Soft Capsule（New Soft Capsule of decoction for removing blood stasis in the chest） on the myocardial fibrosis of hypertension patients.Methods Sixty cases of hypertension accompanied with myocardial fibrosis were randomized into western medicine group and Chinese medicine group

30 in each.The western medicine group was administered antihypertensive agents of angiotension-coverting enzyme inhibitors（ACEI）

in addition

the Chinese medicine group was given New Xuefu Zhuyu Soft Capsule.Both groups were treated for 12 weeks

and before and after treatment

the level of oxidized low density lipoproteins（ox-LDL）

nitric oxide（NO）

procollagen Ⅰcarboxyterminal propeptide（PⅠCP）

procollagen Ⅲ（PCⅢ）

transforming growth factor-β1（TGF-β1）

and endothelin（ET） was determined.Results After treatment

the levels of ox-LDL

ET

PⅠCP

PCⅢ and TGF-β1 in both groups were decreased

while the level of NO was significantly increased

compared with those before treatment

the difference was statistically significant（P<0.01）.Compared with those in the western medicine group

the levels of ox-LDL

ET

PⅠCP

PCⅢ

TGF-β1

and NO in the Chinese medicine group were also statistically different（P<0.01）.Conclusion New Xuefu Zhuyu Soft Capsule is effective to regulate the blood lipid

improve the endothelial function

decrease the myocardial collagen content

and significantly suppress the proliferation of vascular smooth muscle cells to reverse myocardial fibrosis.