Objective To observe the effect of Xiaoyan Decoction （Herbal decoction for cancer） plus 125I particle implantation and high frequency thermotherapy on the lung cancer of late stage.Methods Thirty-nine cases of the late stage lung cancer were divided into 3 groups: Xiaoyan Decoction group

Xiaoyan Decoction plus 125I particle implantation group（oral taking Xiaoyan Decoction for 3 days and then 125I particle implantation）

and Xiaoyan Decoction plus 125I particle implantation and high frequency thermotherapy group （oral taking Xiaoyan Decoction for 3 days and then 125I particle implantation

7 days later high frequency thermotherapy in vitro）.After treatment

all patients were re-examined by chest CT to compare the tumor size

and Karnofsky scores

changes of body weight

immune indices（NK cells

T cell subpopulation）

and tumor markers（carcinoembryonic antigen

CEA）

（cellular cutin fragment-19） were observed.Results In the aspect of tumor size

the comparison with before treatment showed that there was no statistical difference after treatment in all 3 groups（P>0.05）.The Xiaoyan Decoction plus 125I particle implantation and high frequency thermotherapy group was effective in decreasing and stabilizing the tumor size.In the aspect of Karnofsky scores

changes of body weight

and immune indices

the comparison with before treatment showed that there was no statistical difference after treatment in all 3 groups（P>0.05）.The Xiaoyan Decoction group and Xiaoyan Decoction plus 125I particle implantation and high frequency thermotherapy group were showing tendency in improving the organism state of patients.Xiaoyan Decoction group presented effect in improving the tiredness

insomnia

and loss of appetite of the patients（P<0.05）.Conclusion Xiaoyan Decoction

125I particle implantation

and high frequency thermotherapy in vitro used in combination is effective on the lung cancer of late stage and these three method have synergy effect.