Objective To approach the correlation among severe blood-stasis syndrome

plasma von Willebrand factor（vWF） and polymorphism of CYP2C19*2 gene in the patients after percutaneous coronary intervention（PCI）.Methods Totally 371 coronary heart disease patients after receiving successful PCI were adopted in this study.One week after operation

they were divided into three groups according to the scoring criteria of blood-stasis syndrome

i.e.non blood-stasis group（77 cases）

mild blood-stasis group（193 cases）

and severe blood-stasis group（101 cases）.The PCR-RFLP gene analyzing method was adopted to detect the polymorphism of CYP2C19*2 gene.At the same time

the platelet count

maximum platelet aggregation（MPA） rate

vWF

and fibrinogen（Fg） were tested.Results Mutations GA+AA of CYP2C19*2 gene was higher in the severe blood-stasis group than in the other two groups（χ2=27.093

P<0.001）.The multifactor logistic regression analysis indicated that taking the non blood-stasis group as control

after adjusting all common risk factors

the odds ratios（OR） of GA+AA of CYP2C19*2 gene diseased with severe blood-stasis was 3.371（95%Cl: 1.557-7.295

P=0.002）.MPA and vWF of the severe blood-stasis group were higher than those of mild blood-stasis group

and the difference was statistically significant（P<0.05）.The ROC curve of vWF indicated that those patients were more likely to be severe blood-stasis when vWF ≥ 118.10%（sensitivity 0.842

specificity 0.767

syndrome differentiation accuracy 78.6%

and Youden index 0.609）.Conclusion Those who have CYP2C19*2 gene mutation after PCI are susceptible to severe blood-stasis

and vWF serves as an important concrete indicator of syndrome differentiation.