Objective To explore the effect and mechanism of Shensu-Ⅱ（Chinese medicine for nephrosis）on the renal tissues of rat models of mesangium proliferative glomerulonephritis（MsPGN）.Methods Forty male SD rats were randomized into four groups

i.e.normal group

model group

western medicine group

and Chinese medicine group

with 10 in each.Except the normal group

the rats were made MsPGN models by using the thymus cell antibody injection.The Chinese medicine group was treated with Shensu-Ⅱ 3.5g/100g through intragastric filling

and the western medicine group treated with Benazepril 0.33mg/100g for control.The intervention was of six weeks in total.From the starting of treatment and at the end of the third and sixth week of treatment

the blood samples of all groups were collected for observing the changes in urine protein in 24h（TP/24h）

blood urea nitrogen（BUN）

and serum creatinine（SCr）;at the end of the sixth week of treatment

the kidneys were cut off for observing the proliferation of mesangium cells and matrix with light microscope

and the expression of interleukin-6（IL-6）.Results In the Chinese medicine group

the excretion of urinary protein and content of BUN and SCr of the MsPGN rat models were significantly reduced

and the difference was significant in comparing with those in the western medicine group（P<0.05）;the proliferation of mesangium cells and matrix were significantly inhibited

and the result of Masson dyeing image analysis showed that there was no significant difference from that of the western medicine group（P>0.05）.IL-6 expression of the renal tissues was significantly down regulated

and the difference was significant in comparing with that in the western medicine group（P<0.05）.Conclusion Shensu-Ⅱ is effective to improve the renal function of MsPGN rat models

reduce its pathological damage

and inhibit the proliferation of membrane cells and matrix and the exessive expression of renal IL-6 as well

thus delaying the progression of disease.