Objective To study the function and mechanism of Fufang Ezhu San （Compound powder of aromatic turmeric） on endometriosis （EM）.Methods The EM models were established by self-endometrium transplantation with 60 Wistar rats.The succeeded endometriosis models were randomized into 5 groups.Fufang Ezhu San low-dosage group

middle-dosage group and high-dosage group was given Fufang Ezhu San 5.85g/（kg.d）

11.7g/（kg.d）

and 23.4g/（kg.d） respectively.Gestrinone of 0.05mg/ （kg.d） was given to the control group.The model control group and blank control group including 8 normal rats were given normal saline 1ml/100g.The intragastric feeding was performed once a day

for 28 days in succession.Expression of matrix metalloproteinases-2 （MMP-2） and vascular endothelial growth factor （VEGF） in the uterus and ectopic endometrial tissues of all groups were detected with immunohistochemical method.Results The expression of MMP-2 and VEGF in the ectopic endometrial tissues were higher than those in the uterus tissues （P<0.05）.Fufang Ezhu San could inhibit significantly the growth of ectopic endometrial tissues

diminish the volume of ectopic foci

and decrease the expression of MMP-2 and VEGF in a dose-dependent manner.Compared with the model control group

the difference was statistically significant （P<0.05）

and the effect was not significantly different as compared with that of gestrinone （P>0.05）.Conclusion Fufang Ezhu San is effective in inhibiting the expression of MMP-2 and VEGF and lowering the invasion of ectopic foci and ability of angiogenesis.This may be one of its mechanisms in treatment of endometriosis.