Objective To explore the functional mechanism of Compound Hyacinth Bletilla Paste in the treatment and prevention of acidic reflux esophagitis.Methods The Wistar rats were randomized into 4 groups

including the sham-operation group

the whole process Chinese medicine group

post-modeling Chinese medicine group

and normal saline group

23 in each.Except the sham-operation group

the other three groups were all made acidic reflux esophagitis models.The whole process Chinese medicine group was administered Compound Hyacinth Bletilla Paste 7 days before modeling through intragastric feeding

3 ml everyday.After modeling

the whole process Chinese medicine group and the post-modeling Chinese medicine group were administered the same dose Chinese medicine;meanwhile the normal saline group was administered the same dose of normal saline through intragastric feeding.Respectively on 7d and 14d after operation

the pH of lower portion of esophagus

gross specimen

and histological changes the esophageal mucosal gastrin（GAS）

motilin（MOT）

vasoactive intestinal peptides（VIP）

and nitric oxide（NO）levels in all groups were detected.Results The two Chinese medicine groups could make the pH of lower portion of esophagus increased

make the injured esophageal mucosa quickly repaired

make the expression of GAS and MOT of esophageal mucosa enhanced

and make the expression of VIP and NO reduced

of which

the effect of whole process Chinese medicine group was more significant

and in comparing with normal saline grown and sham-operation group there was statistical difference（P<0.05）.Conclusion Compound Hyacinth Bletilla Paste functions to treat and prevent the acidic reflux esophagitis through protecting the local mucosa

regulating various gastrointestinal hormones and neurotransmitters

and increasing the pressure of lower esophageal sphincter

and promoting the gastric emptying.