Objective To observe the clinical therapeutic effect of Huazhuo Qingre Decoction（Decoction for dissolving turbidity and clearing heat） for the treatment of diabetics with damp-heat blocking the spleen syndrome.Methods Sixty enrolled patients were randomized into treatment group of 40 cases and control group of 20 cases.The control group was administered Repaglinide 1mg each time

3 times a day

based on which

the treatment group was administered Huazhuo Qingre Decoction one dose a day.The effect of both groups was observed after medication for 2 months.Before and after treatment

the main clinical symptoms were scored

and the fasting blood glucose（FBG）

blood glucose 2h after meal（2hBG）

and glycosylated hemoglobin（GHb） were measured.Results The total effective rate of the treatment group was 85% and that of the control group was 60%

the difference between the two groups was statistically significant（P<0.05）.The score of main symptoms of both groups

FBG

2hBG

and GHb were all reduced after treatment（P<0.05 or P<0.01）.The improvement of symptoms including fatigue

heaviness of the head and body

abdominal distention

and FBG in the treatment group was superior to that in the control group（P<0.01）.Conclusion Huazhuo Qingre Decoction is effective in improving the clinical symptoms and decreasing the blood glucose of the diabetics with damp-heat blocking the spleen syndrome.