Objective To study the curative effect and mechanism of diabetic-foot lotion on the skin ulcer of mice with diabetic foot（DF） induced by streptozotocin（STZ）.Methods Ten of the fifty healthy male Kunming mice were put into the normal group and the other 40 were injected STZ 150mg/kg intraperitoneally after 12h fasting to make model

and were randomized into 4 groups

model control group

insulin group

Diabetic-foot Lotion group

and Jinhuang San control group

with 10 in each.All mice were made skin ulcer models by cutting on one side of the back to produce a skin ulcer approximately 8mm in diameter.Except for the normal control group and model control group

the other three groups were injected insulin

of them

two groups were given Diabetic-foot Lotion and Jinhuang San for exteral application.The body weight

ulcer size

and fasting blood glucose（FBG）.were dynamically observed.After treatment for 30 days in succession and fasted for 8h

c-reactive protein（CRP）

interleukin（IL-6）

and tumor necrosis factor α（TNF-α） were determined.Results The ulcer healing of the Diabetic-foot Lotion group was earlier than that of the model control group

the difference was significant（P<0.01）.and the level of FBG

CRP

IL-6

and TNF-α was lower than that of the model control group

the body weight being higher than that of the model control group with significant differences（P<0.05 or P<0.01）.Conclusion Under the premise of effective control of blood glucose with insulin

the application of Diabetic-foot Lotion quickens the ulcer healing through promoting the granulation tissue growth.Its mechanism is related to the decreases of the inflammatory cell factors.