Objective To observe the clinical effect of Shugan Tiaojing Formula（Formula to relieve the liver stagnation and regulate menstruation）on the polycystic ovarian syndrome（PCOS）patients accompanied with emotional disturbance.Methods Ninety PCOS patients with emotional disturbance were collected and randomized into Chinese medicine group and control group with 45in each.The control group was administered Diane-35and Clomiphene

based on which

the Chinese medicine group was given Shugan Tiaojing Formula additionally

21days as one course

totally 3courses.Before and after treatment

the hormone levels including luteotropic hormone（LH）、follicle stimulating hormone（FSH）、estrodiol（E2）、prolactin（PRL） and testosterone（T）were determined.Before treatment and 4

8

and 12weeks after treatment

the self-rating depression scale（SDS）and self-rating anxiety scale（SAS）were applied for scoring.The 36-item shot-form health status survey（SF-36） was used to observe the life quality of patients.And 6months after treatment

the ovulation rate

pregnancy rate and spontaneous abortion rate were observed.Results The total effective rate in the Chinese medicine group and control group was 84.4%and 62.2%respectively

the difference was significant（P<0.05）.The hormone level of the Chinese medicine group was significantly improved

and the SDS and SAS scores 12weeks after treatment were lower than those of the control group（P<0.05）.After treatment

the Chinese medicine group was improved in the scores of physiological role

somatalgia

overall health and vitality

emotional role

and psychological health（P<0.05）.The ovulation rate

pregnancy rate

and spontaneous abortion rate of the two groups were not statistically different（P>0.05）.Conclusion Shugan Tiaojing Formula is effective in enhancing the overall effect and improving the life quality of PCOS patients with emotional disturbance.