Objective To explore the clinical effect of Danhong Injection（Red Sage and Safflower Injection）and Huangqi Injection（Astragalus Injection）on hepatic fibrosis of chronic hepatitis B.Methods Totally 198cases of hepatic fibrosis of chronic hepatitis B were randomized into a treatment group of 113cases and a control group of 85cases.The treatment group was given Danhong Injection

Huangqi Injection

and Diammonium Glycyrrhizinate Injection for treatment

while the control group was treated with Diammonium Glycyrrhizinate Injection only

once a day

60days as one course.Before treatment and 3months after treatment

the changes in the indices of serum hyaluronic acid（HA）

procollagenⅢ（PC-Ⅲ）

laminin（LN）

Ⅳ collagen（Ⅳ-C）

liver function

and clinical effect were observed.Results The total effective rate was 86%（97/113）and 59%（50/85）in the treatment group and control group respectively

with statistical difference（P<0.05）.The liver function of the two groups was improved after treatment and the improvement in the treatment group was more significant（P<0.05）.A decrease of HA

PC-Ⅲ

LN

andⅣ-C of both groups after treatment was significant（P<0.01）

and the decrease was more significant in the treatment group than in the control group（P<0.01）.Conclusion Danhong Injection and Huangqi Injection combined with Diammonium Glycyrrhizinate Injection is effective on hepatic fibrosis of chronic hepatitis B

and could significantly improve the indices of hepatic fibrosis and liver function.