Objective To explore the mechanism of Huazhuo Jiedu Huoxue Tongluo method（method to dissolve turbidity

remove toxic substance

activate blood

and remove obstruction in meridian）on cerebral ischemia reperfusion injury（CIRI）model mice.Methods Fifty Kunming mice were randomized into sham-operated group

model group

Chinese medicine highdose group

Chinese medicine low-dose group

and Nimodipine group

with 10in each.Except the sham-operated group

the other 4groups were made CIRI models of right middle cerebral artery with a thread embolism method.After successful modeling

physiological saline 20ml/（kg·d）was given to the sham-operated group and model group

Nimodipine solution 19.6g/（kg·d）was given to the Nimodipine group

and Chinese medicine Huazhuo Jiedu Huoxue Tongluo decoction high-dose 19.6g/（kg·d）and low-dose 9.8g/（kg·d）were given respectively to the Chinese medicine groups through intragastric feeding

once a day.Fourteen days later

the behavioral changes and the pathomorphological change in the hippocampal CA1region were observed.Results Compared with the model group

high-dose decoction could improve the learning and memory ability and the morphologic manifestation of nerve cells in the hippocampal CA1region of mice and the effect was supeior to the low-dose group and Nimodipine group（P<0.05）.Conclusion Huazhuo Jiedu Huoxue Tongluo method functions to protect the behavioral ability and nerve cells in hippocampal CA1region of mice with CIRI

which might be one of the mechanisms of the method on CIRI.