Objective To observe the effect of dispersion with pungent and purgation with bitter method on patients of precancerous lesions of chronic atrophic gastritis.Methods Totally 80 patients of precancerous lesions of chronic atrophic gastritis were randomized into treatment group and control group with 40 in each.The treatment group received Weikangning granules for oral taking

each time 2g

3 times a day.While the control group received Weifuchun tablets for oral taking

each time 4 tablets

3 times a day.Both groups were treated for 6 months.Comprehensive effect

effect of endoscopic changes and pathological changes after treatment of both groups were observed.Results The total effective rate of integrate effect in the treatment group was 87.5% and that of the control group was 82.5%

the difference was statistically significant （P<0.05）.The total effective rate of endoscopic changes in the treatment group was 75.0% and that of the control group was 45.0%

the difference was statistically significant （P<0.05）.After treatment

gastric inflammation

atrophy and intestinal metaplasia of the treatment group were significantly improved （P<0.05） and dysplasia was no significant improvement （P>0.05）.Conclusion Weikangning granule which is composed upon dispersion with pungent and purgation with bitter method is able to significantly relieve clinical symptoms and reduce gastric inflammation

atrophy and intestinal metaplasia of patients of precancerous lesions of chronic atrophic gastritis.