Objective To observe the intervention effect of notoginseng total glucoside on the dimethylnitrosamine（DMN） induced hepatic fibrosis of rat models. Methods Of the 60 SD rats

10 were randomly selected and put into the normal control group

the rest was made models of hepatic fibrosis to a medium degree induced by DMN.From the 37 successfully made models

8 randomly selected were taken as the model control group.The rest of rats was randomized into notoginseng total glucoside group

8 rats

interferon group

8 rats

notoginseng total glucoside + interferon group

7 rats

and physiological saline negative control group

6 rats.The muscular injection with Freeze-dried Powder Xueshuantong for Injection（Xueshuantong） 1.5mg/100g

Recombinant Human Interferon γ for Injection（INF-γ） 8.675mg/100g

both Xueshuantong and INF-γ

and the physiological saline in the same dosage was given respectively

once a day

8 weeks in succession.The effect on the inflammation and fibrosis degrees of hepatic tissues was evaluated by serum assaying on the indices of liver function and hyaluronic acid（HA） and the results of routine pathological HE and Sirius Red Stains examinations.Results The comparison of TP

Alb

ALT

AST

and HA in the normal control group and all intervention groups with the model control group showed a statistical difference（P<0.05）

the comparison in the model control group with the negative control group showed a statistical difference（P<0.05）

the comparison of the fibrosis score formed by the Semi Scoring System（SSS） of all groups with the model control group respectively showed a statistical difference（P<0.05）

and the comparison of the SSS scores of the notoginseng total glucoside group

interferon group

and the notoginseng total glucoside + interferon group with the model control group respectively showed a statistical difference（P<0.05）.Conclusion The notoginseng total glucoside is effectively improving the liver function

decreasing the serum HA

and improving the pathological degree of hepatic fibrosis of the rat models.