Objective To observe the hypoglycemic effect of Tianmai Xiaoke Tablets [Tablets containing Tianhuafen（Radix Trichosanthis） and Maidong（Radix Ophiopogonis） for diabetes] on diabetes rat models.Methods The diabetes models were established with streptozotocin（STZ） 50mg/kg through intraperitoneal injection.The rat models were randomized into model group

Tianmai Xiaoke Tablets group

simple Chinese medicine group

and chromium picolinate group

with 8 in each.Another 8 healthy rats were taken in the control group.The control group and the model group were treated with normal saline

the simple Chinese medicine group was given Chinese medicine extract 0.197g/kg

the chromium picolinate group was administered chromium picolinate 3.2mg/kg

and the Tianmai Xiaoke Tablets group was prescribed Tianmai Xiaoke Tablets 0.24g/kg each day.The treatment lasted 4 weeks.Blood glucose as well as water and food intake within 24 hours was determined at begining and the end of 2 and 4 weeks;body weight of the rats was measured at the begining and in 4 weeks;glycosylated hemoglobin

insulin and blood lipid were determined at the end of the experiment. Results At the end of experiment

the blood glucose

glycosylated hemoglobin

body weight

and water and food intake of the Tianmai Xiaoke Tablets group and chromium picolinate group were lower than those of the model group

and the difference was significant（P<0.05）.Those of the simple Chinese medicine group decreased but without statistical significance（P>0.05）.The insulin level of diabetic rats was significantly increased

and that of the Tianmai Xiaoke Tablets group and the chromium picolinate group was significantly lowered than that of the model group（P>0.05）.Conclusion The chromium picolinate of the Tianmai Xiaoke Tablets has synergistic action with the ingredient of Chinese medicine

being effective in decreasing the blood glucose and improving the symptoms of diabetes of the diabetic rats.