Objective To observe the effect of sequential of Fuzheng Jiedu Huoxue Capsule （Capsule for reinforcing resistance

removing toxins

and activating blood circulation） treatment on chronic hepatitis B （CHB）. Methods Totally 91 CHB patients were randomized into two groups. The control group of 45 cases were administered lamivudine tablets

bifendate pills

and inosine tablets. Additionally

the treatment group was given sequentially Ⅰ

Ⅱ

and Ⅲ

each for 90 days. The course of treatment was 270 days in total. Before treatment and on the 30th

60th

90th

180th

and 270th day of treatment

the liver function

hepatitis B virus （HBV） five items

HBV-DNA capacity

and indices of liver fibrosis were detected and the main symptom scores were recorded. Results The negative conversion rate of alanine aminotransferase （ALT） in both groups was improved （P<0.05）

but the difference between groups at the same time point was not significant （P>0.05）. The HBV-DNA and the negative conversion rate of HBeAg

the HBsAg/HBsAb

and the transformation rate of HBeAg/HBeAb of the treatment group were all higher than those of the control group

but the difference was not significant （P>0.05）. After treatment

the indices of liver fibrosis of both groups were significantly decreased

but the amplitude of decrease in the treatment group was larger （P<0.05）. The total score of main symptoms in the treatment group was reduced

and the difference between the two groups was statistically significant （P<0.05）. Conclusion The sequential treatment of Fuzheng Jiedu Huoxue Capsule is comprehensively effective on CHB

to a certain degree

it overcomes the resistance and variation of HBV.