Objective To explore the influence of different exogenous pathogens such as wind

cold

damp

heat

on the general situations of mice. Methods Totally 64 Kunming mice were randomized into eight groups

including normal group

wind-cold group

cold-damp group

damp-heat group

immunocompromised group

wind-cold immunocompromised group

cold-damp immunocompromised group

and damp-heat immunocompromised group

with 8 in each. The wind-cold

cold-damp and damp-heat environmental conditions were prepared by climate incubator for making the exogenous enviroment models and cyclophosphamide was given continously for 3 days thorough intraperitoneal injection 80mg/（kg·d） for making the immunocompromised models. The spiritual activities

haircolor

skin

joints

and stools of mice were observed ervery day

and the food consumption

water consumption

and body weight were recorded at regular time for 7 days in succession. Results Compared with the normal group

the food and water consumption in all model groups was significantly decreased

and the growth of body weight was significantly slowed down. Compared with the immunocompromised group

the food consumption in the cold-damp immunocompromised group was decreased

the water consumption in the damp-heat immunocompromised group was decreased

and the body weight of these two groups was reduced than before modeling（P<0.05）. Compared with the corresponding exogenous pathogen groups

the food and water consumption in all exogenous pathogen immunocompromised groups was significantly decreased and the body weight was reduced （P<0.05 or P<0.01）. There was influence on the spiritual activities

haircolor

skin

joints

and stools of all model groups

while the effect was more significant in the exogenous pathogen immunocompromised groups. Conclusion All these three environmental factors affect the general situations of normal and immunocompromised mice and the influence on immunocompromised mice is more significant.