Objective To explore the effect of tripterygium glycosides and administration of Chinese medicine based on differentiation on the coagulation mechanism of Henoch-Schonlein purpura nephritis （HSPN） in children. Methods Sixty-two children cases of HSPN were randomized into two groups

Chinese medicine group of 32 cases was treated with tripterygium glycosides plus Chinese medicine based on differentiation and Xiangdan Injection

and western medicine group of 30 cases was treated with adrenocortical hormone plus heparin and persantine. The treatment was given 12 weeks of 30 cases. The level of D-dimer （D-D）

prothrombin time （PT）

activated partial thromboplastin time （APTT）

fibrinogen （FIB）

and the level of blood platelet （PLT） before and after treatment of both groups were observed. Results After treatment

the levels of PLT

D-D

PT

and FIB of the Chinese medicine group were lower than those of before treatment （P<0.05）. The decrease of PT and D-D after 12 weeks of treatment

and the decrease of FIB after treatment for 4 weeks of the Chinese medicine group were more significant than those of the western medicine group

and the difference was statistically significant （P<0.05）. Conclusion Tripterygium glycosides and administration of Chinese medicine based on differentiation have influence on the coagulation mechanism of HSPN in children

the improvement of D-D

PT

and FIB is superior to that of the adrenocortical hormone plus heparin and persantine group.